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Haemophilus capsule polysaccharide plus diphtheria toxoid is a(n)


A) inactivated whole-agent vaccine.
B) attenuated whole-agent vaccine.
C) conjugated vaccine.
D) subunit vaccine.
E) toxoid vaccine.

F) A) and E)
G) B) and C)

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A reaction that uses the absence of hemolysis of red blood cells to indicate an antigen-antibody reaction is called a(n)


A) agglutination reaction.
B) complement fixation.
C) immunofluorescence.
D) neutralization reaction.
E) precipitation reaction.

F) A) and E)
G) D) and E)

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All of the following are generally used in vaccines EXCEPT


A) toxoids.
B) parts of bacterial cells.
C) live,attenuated viruses.
D) inactivated viruses.
E) antibodies.

F) A) and C)
G) None of the above

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Palivizumab is used to treat respiratory syncytial virus disease.This antiviral drug is a(n)


A) toxoid.
B) monoclonal antibody.
C) vaccine.
D) immunosuppressive.
E) nucleoside analog.

F) B) and D)
G) C) and D)

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Dead Bordetella pertussis can be used in a(n)


A) inactivated whole-agent vaccine.
B) attenuated whole-agent vaccine.
C) conjugated vaccine.
D) subunit vaccine.
E) toxoid vaccine.

F) C) and D)
G) B) and E)

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The clumping of test red blood cells indicates a negative test result (no antibodies against the virus in the patient's serum) in the


A) direct agglutination test.
B) indirect agglutination test.
C) complement-fixation test.
D) precipitation test.
E) neutralization test.

F) A) and B)
G) None of the above

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Which of the following uses fluorescent-labeled antibodies?


A) agglutination
B) complement fixation
C) precipitation
D) flow cytometry
E) neutralization

F) B) and E)
G) A) and B)

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A test used to identify Streptococcus pyogenes in a patient's throat swab is the


A) direct fluorescent-antibody test.
B) indirect fluorescent-antibody test.
C) hemagglutination test.
D) neutralization test.
E) indirect ELISA test.

F) A) and B)
G) A) and E)

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A vaccine against HIV proteins made by a genetically-engineered vaccinia virus that has infected a eukaryotic cell line is a(n)


A) conjugated vaccine.
B) subunit vaccine.
C) nucleic acid vaccine.
D) inactivated whole-agent vaccine.
E) toxoid vaccine.

F) A) and B)
G) C) and D)

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A hybridoma results from the fusion of a(n)


A) B cell with a T cell.
B) B cell with a myeloma cell.
C) antigen with an antibody.
D) antigen with a B cell.
E) myeloma cell with a virus.

F) C) and E)
G) A) and C)

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In your work in a county public health clinic,you encounter parents of a three-month-old who are considering not vaccinating their child.What concerns might the parents raise regarding vaccine safety? As a microbiology student and public health care worker,what do you say to these parents regarding the risks of not vaccinating their child?

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The concerns that parents might raise re...

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Table 18.1 Antibody Titer  Day 1  Day 7  Day 14  Day 21  Patient A 00256512 Patient B 1282565121024 Patient C 0000 Patient D 128128128128\begin{array} { | l | r | r | r | r | } \hline & \text { Day 1 } & { \text { Day 7 } } & \text { Day 14 } & \text { Day 21 } \\\hline \text { Patient A } & 0 & 0 & 256 & 512 \\\hline \text { Patient B } & 128 & 256 & 512 & 1024 \\\hline \text { Patient C } & 0 & 0 & 0 & 0 \\\hline \text { Patient D } & 128 & 128 & 128 & 128 \\\hline\end{array} -In Table 18.1,what is the most likely and reasonable explanation for the results observed in Patient C?


A) The patient has advanced HIV/AIDS,with no ability to make an immune response.
B) The patient was not exposed to the pathogen and has not become infected,so no response is being produced over time.
C) The patient has significantly stronger innate immunity than adaptive immunity mechanisms.
D) The patient is producing a protective adaptive response that doesn't involve antibodies.

E) None of the above
F) A) and C)

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A test used to detect anti-Rickettsia antibodies in a patient's serum is the


A) direct fluorescent-antibody test.
B) indirect fluorescent-antibody test.
C) direct ELISA test.
D) direct agglutination test.

E) A) and B)
F) B) and C)

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In a vaccine preparation,the term "attenuated" means that the agent does NOT replicate.

A) True
B) False

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Describe an ELISA test to detect the presence of HIV antibodies in a patient.

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ELISA, or enzyme-linked immunosorbent as...

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Toxoid vaccines,such as the vaccines against diphtheria and tetanus,elicit a(n)


A) TC cell response.
B) immune complex.
C) dendritic cell proliferation.
D) antibody response against these bacterial toxins.
E) antibody response against gram-positive bacteria.

F) D) and E)
G) A) and B)

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In a recent influenza epidemic,physicians were utilizing a rapid diagnostic test to determine which patients were infected with influenza type A,type B,or not infected with influenza virus.Such a test was not available in the massive 1918 outbreak that killed millions of people around the globe.How might the availability of such a test have impacted that outbreak,and why?

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The availability of a rapid diagnostic t...

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Which of the following are sources of antibodies for serological testing?


A) vaccinated animals
B) cells producing monoclonal antibodies
C) viral cultures
D) vaccinated animals and cells producing monoclonal antibodies
E) vaccinated animals,cells producing monoclonal antibodies,and viral cultures

F) A) and D)
G) A) and B)

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A patient shows the presence of antibodies against diphtheria toxin.Which of the following statements is FALSE?


A) The patient may have the disease.
B) The patient may have had the disease and has recovered.
C) The patient may have been vaccinated.
D) A recent transfusion may have passively introduced the antibodies.
E) The patient was near someone who had the disease.

F) All of the above
G) C) and D)

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One of the objections many people have about vaccinations is the amount and variety of chemicals in them.Many people don't realize how easy the ingredients are to find - they're required in the product inserts for each vaccination produced.Using the internet,go and find a product insert for a typical vaccine (e.g.influenza vaccine,HPV vaccine,hepatitis B vaccine,etc.).Identify each component contained within it,the amount of that component,and briefly describe what that component does.

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One example of a typical vaccine product...

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