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If the gradient of the flux is negative, it means that


A) The concentration at the point where the gradient is negative must be increasing with time.
B) The concentration is at steady state.
C) The flux is positive.
D) The concentration at any point is decreasing with distance.
E) The concentration is constant.

F) A) and B)
G) A) and E)

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The major reason that the apparent diffusion coefficient of Ca2+ in muscle cell cytosol is much lower than in water is that


A) The cytosol is more viscous than water
B) The re are obstacles to the free movement of Ca2+ in the cytosol that aren't present in water
C) Cytosol contains fixed proteins that bind Ca2+, slowing its movement
D) The cytosol moves most electrolytes, but not Ca2+, around by convection
E) Ca2+ causes solidification or gelling of the cytosol

F) All of the above
G) B) and C)

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C

According to the Stokes-Einstein equation, if the radius of one particle is twice the radius of a second particle ( r1 = 2 r2) , then the relative value of their diffusion coefficients should be


A) D 1 = 2 D2
B) D 1 = D2 / 2
C) D 2 = D2 / 4
D) D 1 = D2 / 8
E) D 1 = D2 / 16

F) A) and B)
G) None of the above

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The diffusion coefficient of Na+, K+ and many more solutes is slower in cytosol than in water because


A) The cytosol is more viscous than water
B) There are obstacles to the free movement of ions in the cytosol that aren’t present in water
C) Cytosol contains fixed proteins that bind ions, slowing their movem ent
D) The cytosol moves most electrolytes around by convection
E) Ca2+ causes solidification or gelling of the cytosol

F) C) and E)
G) None of the above

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Diffusion of a small non-electrolyte (D = 0.5 x 10-5 cm2s-1) across a 50 µm cell takes about


A) 2.5 milliseconds
B) 25 milliseconds
C) 2.5 seconds
D) 25 seconds
E) 250 seconds

F) B) and D)
G) B) and C)

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Fick’s second law of diffusion follows from the first law if you apply


A) The continuity equation
B) Poiseuille’s equation
C) LaPlace’s Law
D) The conservation of mom entum
E) The random walk

F) D) and E)
G) B) and D)

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A

The Stokes -Einstein equation is valid only if the diffusing particles are


A) At equilibrium (there is no concentration gradient)
B) Warm
C) Cold
D) Spheres
E) Newtonian

F) B) and C)
G) B) and E)

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Which of the following are appropriate units for a diffusion coefficient?


A) cm s-1
B) Joules s-1
C) N s-1
D) cm 2 s-1
E) cm 3 s-1

F) A) and B)
G) A) and E)

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D

Consider two spherical cells that are identical in all respects except that cell one has a radius that is 20% greater than the radius of cell 2 (r1 = 1.2 r2) . One substance is transported into the cell passively. The relative flow of the material across the membranes of the two cells is given as


A) Q 1 = 1.2 Q 2
B) Q 1 = 1.44 Q 2
C) Q 1 = Q2
D) Q 1 = 1.728 Q 2
E) Cannot be determined from the information given

F) A) and C)
G) A) and B)

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If Ca > Cb and a > b, where a and b are x-coordinates, then


A) The gradient of C is negative and diffusive flux is positive, going from a to b
B) The gradient of C is positive and diffusive flux is negative, going from a to b
C) The gradient of C is negative and diffusive flux is negative, going from b to a
D) The gradient of C is positive and diffusive flux is negative, going from a to b.
E) The gradient of C is negative and diffusive flux is positive, going from b to a.

F) C) and D)
G) A) and D)

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Consider two spherical cells that are identical in all respects except that cell one has a radius that is 20% greater than the radius of cell 2 (r1 = 1.2 r2) . One substance is transported into the cell pass ively. The relative flux of the material across the membranes of the two cells is given as


A) J1 = 1.2 J2
B) J1 = 1.44 J2
C) J1 = J2
D) J1 = 1.728 J2
E) Cannot be determined from the information given.

F) A) and B)
G) C) and E)

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In the random walk derivation of Fick’s Second Law, the diffusion coefficient was equated to


A) λ2/2tc \lambda^{2} / 2 t_{c}
B) kt / β\beta
C) λ\lambda / tc
D) λ2 \lambda^{2} / <v>
E) tc / λ\lambda

F) B) and E)
G) None of the above

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